北海道大学大学院獣医学研究院　動物分子医学教室

研究業績

Chen Y, Miyazono K, Otsuka Y, Kanamori M, Yamashita A, Arashiki N, Matsumoto T, Takada K, Sato K, Mohandas N, Inaba M. Membrane skeleton hyperstability due to a novel alternatively spliced 4.1R can account for ellipsoidal camelid red cells with decreased deformability. Journal of Biological Chemistry 299: 102877 (2023)
Wang S, Kozai M, Mita H, Cai Z, Masum Md, Ichii O, Takada K, Inaba M. REV-ERB agonist suppresses IL-17 production in gdT cells and improves psoriatic dermatitis in a mouse model. Biomedicine & Pharmacotherapy 144: 112283 (2021)
Cai Z, Ishibashi T, Kozai M, Mita H, Wang S, Takada K, Inaba M. ROR agonist hampers the proliferation and survival of post-activated CD8+ T cells through the downregulation of cholesterol synthesis-related genes. Immunology & Cell Biology 99: 288 – 298 (2021)
Ohigashi I, Frantzeskakis M, Jacques A, Fujimori S, Ushio A, Yamashita F, Ishimaru N, Yin D, Cam M, Kelly M, Awasthi P, Takada K, Takahama Y. Thymoproteasome hardwires TCR repertoire of CD8+ T cells in cortex independent of negative selection. Journal of Experimental Medicine 218: e20201904 (2021)
Kiatpakdee B, Sato K, Otsuka Y, Arashiki N, Chen Y, Tsumita T, Otsu W, Yamamoto A, Kawata R, Yamazaki J, Sugimoto Y, Takada K, Mohandas N, Inaba M. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. Journal of Biological Chemistry 295: 8048 – 8063 (2020)
Sajiki Y, Konnai S, Cai Z, Takada K, Okagawa T, Maekawa N, Fujisawa S, Kato Y, Suzuki Y, Murata S, Ohashi K. Enhanced Immunotherapeutic efficacy of anti-PD-L1 antibody in combination with an EP4 antagonist. Immunohorizons 21: 837 – 850 (2020)
Khanom US, Ohigashi I, Fujimori S, Kondo K, Takada K, Takahama Y. TCR affinity for in vivo peptide-induced thymic positive selection fine-tunes TCR responsiveness of peripheral CD8+ T Cells. Journal of Immunology 203: 881 – 887 (2019)
Elewa YHA, Ichii O, Takada K, Nakamura T, Masum MA, Kon Y. Histopathological correlations between mediastinal fat-associated lymphoid clusters and the development of lung inflammation and fibrosis following bleomycin administration in mice. Frontiers in Immunology 9: 271 (2018)
Tani A, Yamazaki J, Nakamura K, Takiguchi M, Inaba M. Case report: Congenital methemoglobinemia in a cat with the reduced NADH-cytochrome b5 reductase 3 activity and missense mutations in CYB5R3. Japanese Journal of Veterinary Research 65: 201 – 206 (2017)
Kondo K, Takada K, Takahama Y. Antigen processing and presentation in the thymus: implications for T cell repertoire selection. Current Opinion in Immunology 46: 53 – 57 (2017)
Takada K, Kondo K, Takahama Y. Generation of peptides that promote positive selection in the thymus. Journal of Immunology 198: 2215 – 2222 (2017)
Takada K, Francois Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y. TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells. Nature Immunology 16: 1069 – 1076 (2015)
Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S. Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells. Nature Communications 6: 7484 (2015)
Takada K, Takahama Y. Positive-selection-inducing self-peptides displayed by cortical thymic epithelial cells. Advances in Immunology 125: 87 – 110 (2015)
Togoo K, Takahama Y, Takada K. Alpha-smooth muscle actin expression identifies subpopulations of mouse lymph node non-hematopoietic cells. Biochemical and Biophysical Research Communications 449: 241 – 247 (2014)
Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y. Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. European Journal of Immunology 44: 561 – 572 (2014)
Takada K, Ohigashi I, Kasai M, Nakase H, Takahama Y. Development and function of cortical thymic epithelial cells. Current Topics in Microbiology and Immunology 373: 1 – 17 (2014)
Otsu W, Kurooka T, Otsuka Y, Sato K, Inaba M. A new class of endoplasmic reticulum export signal ΦXΦXΦ for transmembrane proteins and its selective interaction with Sec24C. Journal of Biological Chemistry 288: 18521 – 18532 (2013)
Sato K, Otsu W, Otsuka Y, Inaba M. Modulatory roles of NHERF1 and NHERF2 in cell surface expression of the glutamate transporter GLAST. Biochemical and Biophysical Research Communications 430: 839 – 845 (2013)
Asano H, Fukunaga S, Deguchi Y, Kawamura S, Inaba M. Bcl-xL and Mcl-1 are involved in prevention of in vitro apoptosis in rat late-stage erythroblasts derived from bone marrow. Journal of Toxicological Sciences 37: 23 – 31 (2012)
Wang CC, Sato K, Otsuka Y, Otsu W, Inaba M. Clathrin-mediated endocytosis of mammalian erythroid AE1 anion exchanger facilitated by a YXXΦ or a noncanonical YXXXΦ motif in the N-terminal stretch. Journal of Veterinary Medical Science 74: 17 – 25 (2012)
Takahama Y, Takada K, Murata S, Tanaka K. β5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells. Current Opinion in Immunology 24: 92 – 98 (2012)
Wang CC, Sato K, Otsuka Y, Inaba M. Cell surface expression and internalization of the murine erythroid AE1 anion exchanger tagged with an extracellular FLAG epitope. Japanese Journal of Veterinary Research 59: 157 – 164 (2011)
Asano H, Deguchi Y, Kawamura S, Inaba M. A simple method for enrichment of polychromatic erythroblasts from rat bone marrow, and their proliferation and maturation in vitro. Journal of Toxicological Sciences 36: 435 – 444 (2011)
Takada K, Wang X, Hart GT, Odumade OA, Weinreich MA, Hogquist KA, Jameson SC. Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells. Journal of Immunology 186: 775 – 783 (2011)
Adachi H, Kurooka T, Otsu W, Inaba M. The forced aggresome formation of a bovine anion exchanger 1 (AE1) mutant through association with δF508-cystic fibrosis transmembrane conductance regulator upon proteasome inhibition in HEK293 cells. Japanese Journal of Veterinary Research 58: 101 – 110 (2010)
Komatsu T, Sato K, Otsuka Y, Arashiki N, Tanaka K, Tamahara S, Ono K, Inaba M. Parallel reductions in Stomatin and Na,K-ATPase through the exosomal pathway during reticulocyte maturation in dogs: Stomatin as a genotypic and phenotypic marker of high K+ and low K+ red cells. Journal of Veterinary Medical Science 72: 893 – 901 (2010)
Arashiki N, Otsuka Y, Ito D, Yang M, Komatsu T, Sato K, Inaba M. The covalent modification of spectrin in red cell membranes by the lipid peroxidation product 4-hydroxy-2-nonenal. Biochemical and Biophysical Research Communications 391: 1543 – 1547 (2010)
Takada K, Takahama Y. Another zinc finger in the pie of CD4-CD8 lineage choice. Nature Immunology 11: 370 – 371 (2010)
Adachi H, Ito D, Kurooka T, Otsuka Y, Arashiki N, Sato K, Inaba M. Structural implications of the EL(K/Q)(L/C)LD(A/G)DD sequence in the C-terminal cytoplasmic tail for proper targeting of anion exchanger 1 to the plasma membrane. Japanese Journal of Veterinary Research 57: 135 – 146 (2009)
Takada K, Jameson SC. Naive T cell homeostasis: from awareness of space to a sense of place. Nature Reviews Immunology 9: 823 – 832 (2009)
Takada K, Jameson SC. Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels. Journal of Experimental Medicine 206: 2253 – 2269 (2009)
Chu HH, Moon JJ, Takada K, Pepper M, Molitor JA, Schacker TW, Hogquist KA, Jameson SC, Jenkins MK. Positive selection optimizes the number and function of MHCII-restricted CD4(+) T cell clones in the naive polyclonal repertoire. Proceedings of the National Academy of Sciences of the United States of America 106: 11241 – 11245 (2009)
Weinreich MA, Takada K, Skon C, Reiner SL, Jameson SC, Hogquist KA. KLF2 Transcription-factor deficiency in T Cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity 31: 122 – 130 (2009)
Otsuka Y, Ito D, Katsuoka K, Arashiki N, Komatsu T, Inaba M. Expression of alpha-hemoglobin stabilizing protein and cellular prion protein in a subclone of murine erythroleukemia cell line MEL. Japanese Journal of Veterinary Research 56: 75 – 84 (2008)
Sato K, Otsuka Y, Arashiki N, Komatsu T, Wang CC, Tamahara S, Inaba M. Identification of genes for two major sialoglycoproteins, glycophorin A and glycophorin C in canine red cell membranes. Japanese Journal of Veterinary Research 55: 103 – 114 (2008)
Konno A, Takiguchi M, Takada K, Usami T, Azumi K, Kubota H, Inaba M, Saegusa J, Kon Y. Identification of a quantitative trait locus regulating B cell-dominant infiltration into autoimmune sialitis lesions of the IQI mouse model of primary Sjögren’s syndrome. Immunogenetics 59: 853 – 859 (2007)
Ito D, Otsuka Y, Koshino I, Inaba M. Lumenal localization in the endoplasmic reticulum of the C-terminal tail of an AE1 mutant responsible for hereditary spherocytosis in cattle. Japanese Journal of Veterinary Research 54: 191 – 197 (2007)
Ito D, Koshino I, Arashiki N, Hirokazu Adachi H, Tomihari M, Tamahara S, Kurogi K, Amano T, Ono K, Inaba M. Ubiquitylation-independent ER-associated degradation of an AE1 mutant associated with dominant hereditary spherocytosis in cattle. Journal of Cell Science 119: 3602 – 3612 (2006)
Ohta H, Adachi H, Takiguchi M, Inaba M. Restricted localization of claudin-16 at the tight junction in the thick ascending limb of Henle’s loop together with claudins 3, 4, and 10 in bovine nephrons. Journal of Veterinary Medical Science 68: 453 – 463 (2006)
Kageyama S, Hirayama H, Moriyasu S, Inaba M, Ito D, Ohta H, Sawai K, Minamihashi A, Onoe S. Genetic diagnosis of band 3 deficiency and sexing in bovine preimplantation embryos. Journal of Veterinary Medical Science 68: 319 – 323 (2006)
Ohta H, Adachi H, Inaba M. Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. Journal of Veterinary Medical Science 68: 149 – 155 (2006)
Takada K, Takiguchi M, Inaba M Different effects on the inflammatory lesions in the lacrimal and salivary glands after neonatal thymectomy in IQI/Jic mice, a model for Sjögren’s syndrome. Journal of Veterinary Medical Science 67: 955 – 957 (2005)
Jeong JR, Yamasaki M, Komatsu T, Inaba M, Yamato O, Maede Y. Identification of heat shock protein 70 in canine reticulocytes and mature erythrocytes. Japanese Journal of Veterinary Research 53: 37 – 46 (2005)
Takada K, Takiguchi M, Konno A, Inaba M. Autoimmunity against a tissue kallikrein in IQI/Jic mice – A model for Sjogren’s syndrome. Journal of Biological Chemistry 280: 3982 – 3988 (2005)
Takiguchi M, Inaba M. Diagnostic ultrasound of polypoid cystitis in dogs. Japanese Journal of Veterinary Research 67: 57 – 61 (2005)
Hirayama H, Kageyama S, Moriyasu S, Hirano T, Sugimoto Y, Kobayashi N, Inaba M, Sawai K, Onoe S, Minamihashi A. Genetic diagnosis of claudin-16 deficiency and sex determination in bovine preimplantation embryos. Journal of Reproduction and Development 50: 613 – 618 (2004)
Kim JY, Yokoyama N, Kumar S, Inoue N, Inaba M, Fujisaki K, Sugimoto C. Identification of a piroplasm protein of Theileria orientalis that binds to bovine erythrocyte band 3. Molecular and Biochemical Parasitology 137: 193 – 200 (2004)
Takada K, Takiguchi M, Konno A, Inaba M. Spontaneous development of multiple glandular and extra-glandular lesions in aged IQI/Jic mice: a model for primary Sjögren’s syndrome. Rheumatology 43: 858-862 (2004)
Konno A, Takada K, Saegusa J, Takiguchi M. Presence of B7-2+ dendritic cells and expression of Th1 cytokines in the early development of sialodacryoadenitis in the IqI/Jic mouse model of primary Sjörgren’s syndrome. Autoimmunity 36: 247 – 254 (2003)
Tamahara S, Inaba M, Sato K, Matsuki N, Hikasa Y, Ono K. Non-essential roles of cysteine residues in functional expression and redox regulatory pathways for canine glutamate/aspartate transporter based on mutagenic analysis. Biochemical Journal 367: 107 – 111 (2002)
Thongsong B, Bonkobara M, Matsumoto M, Jang J, Matsuki N, Inaba M, Ono K. Effects of isulin-like growth factor-I on maternal and fetal plasma amino acid levels in pregnant rats. Journal of Veterinary Medical Science 64: 859 – 861 (2002)
Bonkobara M, B Thongsong B, Ohmori T, Matsuki N, Inaba M, Ono K. Effects of epidermal growth factor on placental amino acids uptake in pregnant rats. Journal of Veterinary Medical Science 64: 689 – 692 (2002)
Boffi FM, Ozaki J, Matsuki N, Inaba M, Desmaras E, Ono K. Effects of chemical ischemia on purine nucleotides, free radical generation, lipids peroxidation and intracellular calcium levels in C2C12 myotube derived from mouse myocytes. Journal of Veterinary Medical Science 64: 483 – 488 (2002)
Yamato O, Matsuki N, Satoh H, Inaba M, Ono K, Yamasaki M, Maede Y. Sandhoff disease in a golden retriever dog. Journal of Inherited Metabolic Disease 25: 319 – 320 (2002)
Matsuki N, Inaba M, Ono K. Catabolism of cytoplasmic and intramitochondrial adenine nucleotides in C2C12 skeletal myotube under chemical hypoxia. Journal of Veterinary Medical Science 64: 341 – 347 (2002)
Thongsong B, Bonkobara M, Matsuki N, Inaba M, Ono K. Effects of insulin-like growth factor-I and epidermal growth factor on placental amino acid uptake in rats. Revue de Medecine Veterinaire 151: 779 – 779 (2000)
Sato K, Inaba M, Suwa Y, Matsuu A, Hikasa Y, Ono K, Kagota K. Inherited defects of sodium-dependent glutamate transport mediated by glutamate/aspartate transporter in canine red cells due to a decreased level of transporter protein expression. Journal of Biological Chemistry 275: 6620 – 6627 (2000)
Uchide T, Onda K, Bonkobara M, Thongsong B, Matsuki N, Inaba M, Ono K. Utilization of Intestinal Triglyceride-rich Lipoproteins in Mammary Gland of Cows. Journal of Veterinary Medical Science 61: 1143 – 1146 (1999)
Matsumoto M, Inaba M, Ono K. Molecular basis of bovine red-cell protein 4.2 polymorphism in Japanese black cattle. Biochemical Journal 332: 183 – 187 (1998)
Inaba M, Yawata A, Koshino I, Sato K, Takeuchi M, Takakuwa Y, Manno S, Yawata Y, Kanzaki A, Sakai J, Ban A, Ono K, Maede Y. Defective anion transport and marked spherocytosis with membrane instability caused by hereditary total deficiency of red cell band 3 in cattle due to a nonsense mutation. Journal of Clinical Investigation 97: 1804 – 1817 (1996)
Sato K, Inaba M, Maede Y. Characterization of Na+-dependent l-glutamate transport in canine erythrocytes. Biochimica et Biophysica Acta 1195: 211 – 217 (1994)
Inaba M, Maede Y. The critical role of asparagine-502 in posttranslational alteration of protein-4.1. Comparative Biochemistry and Bhysiology B 103: 523 – 526 (1992)
Goto I, Kamada M, Inaba M, Maede Y. Detection of equine immunoglobulin-secreting cells by a plaque-assay. Japanese Journal of Veterinary Research 40: 13 – 18 (1992)
Deamidation of human erythrocyte protein 4.1: possible role in aging. Inaba, M., Gupta, K.C., Kuwabara, M., Takahashi, T., Benz Jr EJ, Maede Y. Blood 79: 3355 – 3361 (1992)
Inaba M, Maede Y. O-n-acetyl-d-glucosamine moiety on discrete peptide of multiple protein-4.1 isoforms regulated by alternative pathways. Journal of Biological Chemistry 264: 18149 – 18155 (1989)
Maede Y, Kuwabara M, Sasaki A, Inaba M, Hiraoka W. Elevated glutathione accelerates oxidative damage to erythrocytes produced by aromatic disulfide. Blood 73: 312 – 317 (1989)
Inaba M, Maede Y. Inherited persistence of immature type pyruvate-kinase and hexokinase isozymes in dog erythrocytes. Comparative Biochemistry and Physiology B 92: 151 – 156 (1989)
Inaba M, Maede Y. A new major transmembrane glycoprotein, gp155, in goat erythrocytes – isolation and characterization of its association to cytoskeleton through binding with band 3-ankyrin complex. Journal of Biological Chemistry 263: 17763 – 17771 (1988)
Inaba M, Maede Y. Correlation between protein 4.1a/4.1b ratio and erythrocyte life-span. Biochimica et Biophysica Acta 944: 256 – 264 (1988)
Inaba M, Maede Y. Energy-metabolism in canine erythrocytes associated with inherited high Na+-stimulated and K+-stimulated adenosine-triphosphatase activity. American Journal of Veterinary Research 48: 114 – 118 (1987)
Inaba M, Maede Y. Na,K-ATPase in dog red-cells – immunological identification and maturation-associated degradation by the proteolytic system. Journal of Biological Chemistry 261: 6099 – 6105 (1986)
Inaba M, Maede Y. Stability of [3H]ouabain binding to the (Na+, K+)-ATPpase solubilized with C12E8. Biochimica et Biophysica Acta 818: 267 – 270 (1985)
Inaba M, Maede Y. Na,K-ATPase in dog red cells. Immunological identification and maturation-associated degradation by the proteolytic system. Journal of Biological Chemistry 260: 3337 – 3343 (1985)
Inaba M, Maede Y. Increase of Na+ gradient-dependent L-glutamate and L-aspartate transport in high K+ dog erythrocytes associated with high activity of (Na+, K+)-ATPase. Journal of Biological Chemistry 259: 312 – 317 (1984)
Maede Y, Inaba M, Taniguchi N. Increase of Na-K-ATPase activity, glutamate, and aspartate uptake in dog erythrocytes associated with hereditary high accumulation of GSH, glutamate, glutamine, and aspartate. Blood 61: 493 – 499 (1983)